Participación del miR-137 en el cáncer

Authors

  • AV Cervantes-Ayala Laboratorio de Genómica Funcional de la Unidad de Investigación Médica en Genética Humana del Hospital de Pediatría “Silvestre Frenk Freund”, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (IMSS).
  • R Ruiz Esparza-Garrido Laboratorio de Genómica Funcional de la Unidad de Investigación Médica en Genética Humana del Hospital de Pediatría “Silvestre Frenk Freund”, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (IMSS).
  • MÁ Velázquez-Flores Laboratorio de Genómica Funcional de la Unidad de Investigación Médica en Genética Humana del Hospital de Pediatría “Silvestre Frenk Freund”, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (IMSS).

Keywords:

microRNAs, miR-137, neurogenesis, cancer

Abstract

MicroRNAs are small RNAs (18-100 nucleotides), which regulate the expression of their target genes at the post-transcriptional level; however, miRNAs have been detected at the nuclear level. MicroRNA hsa-mirR-137 is located within its host gene MIR137HG, in the locus 1p21.3, and regulates genes involved in cell proliferation and cell differentiation. This microRNA participates on the neurogenesis by suppressing the proliferation of neural stem cells and by promoting their differentiation. Because of these crucial functions, its participation has been focussed on the study of different neurological diseases and in cancer, where it functions as tumoral suppressor (nervous system tumors, melanoma, gastric and lung cancer, oral carcinoma, osteosarcoma, ovarian and breast cancer) or oncogene (bladder and breast cancer). According to these studies, miR-137 could function as a biomarker for diagnosis and prognosis, and as therapeutic target in many types of cancer; however, more studies are needed to establish these.

Author Biography

R Ruiz Esparza-Garrido, Laboratorio de Genómica Funcional de la Unidad de Investigación Médica en Genética Humana del Hospital de Pediatría “Silvestre Frenk Freund”, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (IMSS).

Catedrática Conacyt,  Naturaleza del trabajo: síntesis de
información (Revisión).

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Published

2018-08-17

Issue

Vol. 15 No. 2 (2018)

Section

Artículos de Investigación Original